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Neurointervention > Volume 11(2); 2016 > Article
Ihn, Kim, Byun, Suh, Won, Lee, Kim, Kim, Jeon, Ryu, Suh, Choi, Choi, Choi, Chang, Lee, Kim, Lee, Shin, Lim, Yoon, Jeong, and Han: Patient Radiation Exposure During Diagnostic and Therapeutic Procedures for Intracranial Aneurysms: A Multicenter Study

Abstract

Purpose

To assess patient radiation doses during cerebral angiography and embolization of intracranial aneurysms across multi-centers and propose a diagnostic reference level (DRL).

Materials and Methods

We studied a sample of 490 diagnostic and 371 therapeutic procedures for intracranial aneurysms, which were performed at 23 hospitals in Korea in 2015. Parameters including dose-area product (DAP), cumulative air kerma (CAK), fluoroscopic time and total angiographic image frames were obtained and analyzed.

Results

Total mean DAP, CAK, fluoroscopy time, and total angiographic image frames were 106.2 ± 66.4 Gy-cm2, 697.1 ± 473.7 mGy, 9.7 ± 6.5 minutes, 241.5 ± 116.6 frames for diagnostic procedures, 218.8 ± 164.3 Gy-cm2, 3365.7 ± 2205.8 mGy, 51.5 ± 31.1 minutes, 443.5 ± 270.7 frames for therapeutic procedures, respectively. For diagnostic procedure, the third quartiles for DRLs were 144.2 Gy-cm2 for DAP, 921.1 mGy for CAK, 12.2 minutes for fluoroscopy times and 286.5 for number of image frames, respectively. For therapeutic procedures, the third quartiles for DRLs were 271.0 Gy-cm2 for DAP, 4471.3 mGy for CAK, 64.7 minutes for fluoroscopy times and 567.3 for number of image frames, respectively. On average, rotational angiography was used 1.5 ± 0.7 times/session (range, 0-4; n=490) for diagnostic procedures and 1.6 ± 1.2 times/session (range, 0-4; n=368) for therapeutic procedures, respectively.

Conclusion

Radiation dose as measured by DAP, fluoroscopy time and image frames were lower in our patients compared to another study regarding cerebral angiography, and DAP was lower with fewer angiographic image frames for therapeutic procedures. Proposed DRLs can be used for quality assurance and patient safety in diagnostic and therapeutic procedures.

Cerebrovascular disease is one of the leading causes of death in Korea, and there has been a corresponding increase in the number and complexity of interventional neuroradiology (INR) procedures. This increase is attributable to both technological advancements and evidence favoring endovascular techniques over conventional surgery [1]. However, interventional radiological procedures have the potential to exposure a patient to high doses of radiation, and, in particular, a high entrance surface dose of up to several Gy. Surface skin dose is important because of the potential for well-documented deterministic effects, such as skin epilation, erythema and desquamation. Dose thresholds for these lesions are in the order of 3 Gy, 6 Gy and 15 Gy, respectively [2]. Additionally, INR procedures, like all sources of radiation exposure, can cause stochastic risks by way of cancer. Direct measurement of surface skin dose is desirable, but not practical because thermoluminescent dosimeters (TLD) are cumbersome with limitations in terms of practical use [3]. An indirect estimate of the radiation dose using a dose-area product (DAP) meter, which is common in modern angiographic systems, can be an alternative.
A diagnostic reference level (DRL) is an investigational level used to identify unusually high radiation doses for common diagnostic medical X-ray imaging procedures. DRLs are suggested action levels above which a facility should review its method and determine if an acceptable image quality can be achieved at lower doses [4]. It is typically set as the 75th percentile of measured patient or phantom data. Commonly used parameters for a DRL dose are dose area product (DAP), number of exposures and fluoroscopy time.
Previous studies in Korea and other countries have investigated DRL levels, and reported a large variation within hospitals using different DRL guidelines [5,6,7]. Recognizing the need for continuous monitoring of the dose in INR procedures and the fact that no such multi-center study has ever been carried out in Korea so far, the authors have collected data concerning the dose to patients undergoing some of the most common diagnostic and therapeutic INR procedures performed in Korea.
The purposes of present study were: (1) to obtain baseline data by evaluation of patient exposure at multi-centers, (2) to compare these data with the recent literature from other studies, and (3) to propose DRLs.

MATERIALS AND METHODS

This study was approved by our Institutional Review Board. A waiver of the need for consent was obtained for the Health Insurance Portability and Accountability Act compliant survey research.
The study included patients undergoing INR procedures from October 2015 through to December 2015. Twenty-three university hospitals in Korea were invited to participate in the study. Each center was asked to register 20 diagnostic and 15 therapeutic INR procedures. As the radiation doses show a wide distribution with respect to pathology and type of INR procedure, we focused on a more standardized examination, such as diagnostic cerebral angiography and therapeutic embolization for an intracranial aneurysm. For each examination, the centers were requested to fill out a questionnaire containing various information regarding radiation data. The X-ray systems used in this study were all biplane DSA (15 Siemens, 7 Philips and 1 GE machines.).

Procedures included

The INR procedures were divided into two groups: first, diagnostic cerebral angiography for aneurysm evaluation; and second, therapeutic procedures, namely aneurysmal coil embolization. Diagnostic procedures performed for follow-up after clipping or coiling of an aneurysm were excluded. The procedures were performed by an experienced interventional neuroradiologist or a clinical fellow undergoing interventional neuroradiology training, all using their own protocols.

Data collection

The patient's demographic information was excluded for each procedure. Collected patient radiation dose indicators were as follows: DAP (Gy-cm2), cumulative air kerma (CAK), fluoroscopic exposure time, number of angiographic image acquisitions. Collected data from AP and lateral views were added together and compared for analysis. The number of rotational angiographic acquisitions in each session of diagnostic and therapeutic procedures was also surveyed. Data were analysed to assess mean ± standard deviation for each parameter. As collected radiation doses showed a skewed distribution with extreme values and a long upper tail, 75th percentile values were also analysed to propose DRLs.

RESULTS

A total of 861 patients were included in this survey, with 490 diagnostic and 371 therapeutic procedures. The results, including the third quartiles, are presented in Table 1. In diagnostic cerebral angiography, mean DAP ± standard deviation were 106.2 ± 66.4 Gy-cm2 for DAP, 697.1 ± 473.7 mGy for CAK, 9.7 ± 6.5 minutes for fluoroscopic time, and 241.5 ± 116.6 frames for total angiographic image frames. For therapeutic procedures, mean DAP ± standard deviation was 218.8 ± 164.3 Gy-cm2 for DAP, 3365.7 ± 2205.8 mGy for CAK, 51.5 ± 31.1 minutes for fluoroscopic time, and 443.5 ± 270.7 frames for total angiographic image frames. The third quartiles, which may be set as a DRL were 144.2 and 271.0 Gy-cm2 for DAP, 921.1 and 4471.3 mGy for cumulative air kerma, 12.2 and 64.7 minutes for fluoroscopy times and 286.5 and 567.3 for the number of image frames in diagnostic and therapeutic procedures, respectively. The distribution plots of the two types of INR procedures in all hospitals are shown in Figure 1 and 2. On average, rotational angiography was used 1.5 ± 0.7 times/session (range, 0-4; n=490) for diagnostic procedures and 1.6 ± 1.2 times/session (range, 0-4; n=368) for therapeutic procedures, respectively.

DISCUSSION

Dose-area product (DAP) action levels are defined as levels of radiation that indicate skin exposures necessitating medical follow-up for possible radiation injuries. DAP action levels do not provide a guideline for optimizing the dose in relation to both medical benefit and risk of injury. However, DRLs do. Comparing the local values with proposed DRLs gives an idea of how the current practice in a hospital ranks with respect to the patient's dose [8].
Tables 2 and 3 present comparisons between our results and those published in the literature [6,7,9,10,11]. With 861 total cases, our study is the largest to date regarding cerebral aneurysms for a proposed DRL. For cerebral angiographic procedures associated with aneurysms, mean DAP, fluoroscopy time and number of angiographic frames were lower in our patients than in the other studies. For cerebral embolization procedures, our data showed comparatively lower DAP, longer fluoroscopy times, and fewer angiographic image frames compared to previous reports. The RAD-IR study [11] reports mean DAP values of 320 Gy-cm2 for 382 cases, including embolization of aneurysm, AVM and tumors. Vano et al. [14] reports a mean DAP of 305 Gy-cm2 and median DAP value of 256 Gy-cm2 for 172 embolization procedures. However, D'Ercole et al. [9] reports a higher median value of 352 Gy-cm2 for 82 embolization procedures.
The results on skin doses are difficult to compare with other studies because different metrics have been used. Some authors report peak skin dose, measured or estimated [3,9,11,12,13], whereas we report DAP and reference air kerma as displayed by the angiography system. The mean skin absorbed doses in our study were 697.1 and 3365.7 mGy in diagnostic and therapeutic procedures, respectively. The RAD-IR study [11] also reports mean CAK values of 3.8 Gy for interventional neuroradiology procedures with aneurysms and AVMs. The study by Vano et al. [14] reported a CAK mean of 2.7 Gy and a CAK third quartile value of 3.9 Gy for cerebral embolizations. Our value of mean CAK 3.4 Gy was within the range of previous published reports, and in concordance with the data in previously published reports, this suggests that our findings provide at least approximate applicability to other hospitals. The term "cumulative skin dose," introduced by ICRP (International Commission on Radiologic Protection), is used in this article as the value of the dose in air, accumulated at the entrance of the patient during the whole interventional procedure. It is obtained from the air kerma accumulated at a specific point in space relative to the fluoroscopic gantry. The "cumulative skin dose" is not the same quantity as the "peak skin dose (PSD)" (i.e., the highest dose on any portion of a patient's skin during a procedure) [14]. PSD measurement is the best indicator for assessing the likelihood of deterministic effects. Unfortunately, PSD measurement is complex and this capability is not yet widely available. Cumulative skin dose is a reasonable alternative [11]. The ICRP has recommended that maximum cumulative absorbed doses to the skin approaching or exceeding 1 Gy (for procedures that may be repeated) or 3 Gy (for any other procedure) should be recorded in the patient's record and that there should be follow-up procedures for such cases [15].
From figure 3, we observed large dose variations for the procedures between different hospitals, even within the same procedure type. As an example, mean DAPs range from between 51.9 and 247.6 Gy-cm2 and fluoroscopy times range from between 3.5 to 18.6 minutes for diagnostic angiography. This is caused by inter-institutional differences in procedure complexity, study protocol, equipment, practitioner skill and technique. Struelens et al. [16] suggested that a large dose variation is caused by a difference in the number of frames, number of projections and exposure parameters. Furthermore, Neofotistou et al. [17] attributed higher doses to teaching hospitals in their study, as it is known that in their first year of training, operators use higher levels of radiation due to extended fluoroscopy.
Regarding the diagnosis and treatment of cerebral aneurysms, rotational angiography facilitates evaluation of the potential for endovascular treatment, permits finding a good working view, aids in performing accurate measurements, depicts additional aneurysms, enables accurate determination of stent positions during stent-assisted coiling, and evaluates subarachnoid hemorrhage during the therapeutic procedure [18,19,20]. Our study showed that rotational angiography was used more frequently in therapeutic procedures than diagnostic angiography (1.63 vs. 1.45 times/session), likely due to complexity of the procedure.
Setting up DRLs for dose-intensive examinations involving fluoroscopy is a difficult task due to the large variability of the fluoroscopic time and the number of images leading to a wide distribution of patient doses. This is due to several factors, including the often loose def inition of the examination, differences in the techniques and protocol used, the variability in the complexity of the cases and the experience of the radiologist [7]. DRLs cannot be used individually on a patient basis and are not a restrictive threshold, but do provide a practical guideline for monitoring and comparing radiation doses among procedures and institutions [8].
Unique institutional patterns and operator preferences for INR procedures can cause difficulty in making radiation dose comparisons between hospitals. Nevertheless, this study would indicate that most Korean university hospitals are delivering appropriate levels of radiation to patients during INR procedures. Our proposed DRL would be of value in comparing and monitoring radiation dose. There are a wide variety of INR procedures with varying complexity which are continuously progressing, so radiation dose may be higher with complex, newer or meticulous procedures. Nevertheless, it is each practitioner's responsibility to investigate his or her own practice and to limit unnecessary radiation exposure according to the ALARA (As Low as Reasonably Achievable) principle [21].
This study has limitations. First, we reviewed a prospectively collected database of diagnostic cerebral angiograms. Inclusion criteria included consecutive patients undergoing diagnostic cerebral angiography from September to December in 2015. We did not evaluate the complexity of the proceudures. Duration of fluoroscopic exposure for each procedure was strongly dependent on the individual clinical circumstances. Second, we selected institutions at which INR procedures were performed frequently, which might have biased the results. Further investigation with larger populations and prospective evaluation is clearly warranted in order to validate our results.

CONCLUSIONS

In the present study, radiation dose as measured by DAP, fluoroscopy time and image frames were lower in our patients than in other studies involving cerebral angiography, and DAP was lower with fewer angiographic image frames regarding aneurysm embolization. We proposed 144 Gy-cm2 and 271Gy-cm2 as DRLs for diagnostic and therapeutic procedures, respectively. A national registry of radiation dose is a necessary next step to refine the reference level.

Acknowledgements

This study was supported by the Korean Society of Interventional Neuroradiology (KSIN) research grant. The authors wish to thank the nurses, technical personnel and staff of interventional neuroradiology at all hospitals involved in this study for their participation and their help with dose measurements.

References

1. Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005;366:809–817.
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Fig. 1

Distribution of the DAP, cumulative air kerma, fluoroscopy time and number of frames for diagnostic procedures. Dashed lines represent third quartile.

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Fig. 2

Distribution of the DAP, cumulative air kerma, fluoroscopy time and number of frames for aneurysm embolization. Dashed lines represent third quartile.

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Fig. 3

Comparison of the mean values of the DAP, cumulative air kerma, fluoroscopy time and number of frames for diagnostic and therapeutic procedures for multi-centers. The alphabet of x-axis represents the various hospitals.

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Table 1

Mean and Third Quartile Data for DAP, Cumulative Air Kerma and Image Frames for Diagnostic and Therapeutic Procedure

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Sample size DAP(Gy- cm2) Cumulative Air Kerma (mGy) Fluoroscopy time (min) Number of image frames
Diagnostic cerebral angiography 490 patients Mean±SD 106.2 ± 66.4 697.1 ± 473.7 9.8 ± 6.5 241.5 ± 116.6
Median 89.4 511.3 7.3 228.5
3rd quartile 144.2 921.1 12.2 286.5
Range 15.5 - 468.0 102.2 - 3058.0 1.1 - 42.4 52 - 844
25th percentile 54.9 362 12.2 155
Interventional cerebral embolization for aneurysm 371 patients Mean±SD 218.8 ± 164.3 3365.7 ± 2205.8 51.5 ± 31.1 443.5 ± 270.7
Median 179.0 2804.0 44.5 412.5
3rd quartile 271.0 4471.3 64.7 567.3
Range 20.0 - 1154.4 486.9 - 11256.0 4.9 - 251.8 57 - 1441
25th percentile 104.5 1691.8 30.4 241.5

Note.- DAP = dose-area product

Table 2

Review of Mean and Third Quartile Data of DAP, Fluoroscopic Time and Number of Image Frames Acquired During Diagnostic Cerebral Angiography for Intracranial Aneurysms

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Reference No. of Patients DAP(Gy-cm2) Fluoroscopy Time (Min) Number of Frames
Mean 3rd Quartile Mean 3rd Quartile Mean 3rd Quartile
This study 490 106.2 144 9.8 12.2 242 287
Aroua et al.(7,) 91 121 125 12.6 15 679 480
D'Ercole et al.(9,) 100 142.1 180 9.9 12.3 220 317
Brambilla et al.(10,) 188 158 198 13.7 17.5
Chun et al.(6,) 439 136.6 154.2 12.6 14.0 251 273

Note.- DAP = dose-area product

Table 3

Review of Mean and Third Quartile Data of DAP, Fluoroscopic Time and Number of Image Frames Acquired During Coil Embolization of Intracranial Aneurysms

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Reference No. of Patients DAP(Gy-cm2) Fluoroscopy Time (Min) Number of Frames
Mean 3rd Quartile Mean 3rd Quartile Mean 3rd Quartile
This study 371 218.8 271 51.5 64.7 444 567
Aroua et al.(7,) 52 335 440 36.5 50 760 800
D'Ercole et al.(9,) 72 382.2 487 37.2 46.3 558 717
Chun et al.(6,) 111 226.0 272.8 52.9 61.1 241 276
Miller et al.(11,) 356 319.9 87.1 1053

Note.- DAP = dose-area product



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