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Neurointervention > Epub ahead of print
DOI: https://doi.org/10.5469/neuroint.2019.00073    [Epub ahead of print]
Published online July 15, 2019.
Off-Label Application of Pipeline Embolization Device for Intracranial Aneurysms
Buqing Liang1,2, Walter S. Lesley1,2, Timothy M. Robinson1,2, Wencong Chen3, Ethan A. Benardete1,2, Jason H. Huang1,2
1Department of Neurosurgery, Baylor Scott & White Health, Temple, TX, USA
2Texas A&M University HSC-COM, Temple, TX, USA
3Department of Biostatistics, Baylor Scott & White Research Institute, Temple, TX, USA
Corresponding author:  Buqing Liang, Tel: +1-254-724-5788, Fax: +1-254-724-5779, 
Email: buqing@buqing.org
Received: 17 March 2019   • Revised: 22 May 2019   • Accepted: 3 June 2019
Abstract
Purpose
The Pipeline embolization device (PED) is approved in the USA for treating giant and large aneurysms arising from the petrous to superior hypophyseal segments of the internal carotid artery in patients older than 21 years of age. This study investigates off-label PED results in a large cohort.
Materials and Methods
Retrospective, single-center review of all patients who had off-label PED surgery.
Results
Sixty-two aneurysms (48 patients) underwent off-label PED treatment from 2012– 2017. There were 44 females and four males (age 21 to 75 years; mean/median, 54.3/55.0 years). The most common presenting symptom was headache (47/62, 75.8%). All aneurysms were in the anterior circulation. Aneurysm size ranged from 1.4 to 25.0 mm (mean/median, 7.6/6.9 mm). Fifty-two aneurysms had post-operative imaging with total/near-complete occlusion of 84.6% (44/52). Aneurysm-based operative near-term complication rate was 9.7% while there were no permanent complications. For aneurysms and headache, 86.7% improved/resolved after embo-surgery, and were four times more likely to have a better clinical outcome (resolved or improved symptoms) after surgery (odds ratio [OR], 4.333; P=0.0325). Left-sided aneurysms had a higher occlusion rate (OR, 20; P=0.0073). Hypertension (OR, 4.2; P=0.0332) and smoking (OR, 7; P=0.0155) were more prone towards aneurysm occlusion. Patients without a family history were 14 times more likely to have favorable imaging outcome (P=0.0405). There is no difference of occlusion rates between untreated and previously treated aneurysms (P=0.6894). Overall, occlusion rate decreased by 14% with an increase of aneurysm size by 1 mm (P=0.0283).
Conclusion
For anterior circulation aneurysms, the off-label application of PED is as effective and safe as reported for on-label intracranial aneurysms.
Key Words: Pipeline embolization device; Intracranial aneurysm


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