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Neurointervention > Volume 16(1); 2021 > Article
Sundar, Paulraj, Choudhury, Hassan, Sengupta, and Pattari: Successful Endovascular Treatment of Cerebral Venous Thrombosis with a Novel, Larger Aspiration Catheter (REACT): A Case Report


Cerebral venous thrombosis (CVT) is a rare clinical entity, with clinical presentations extending from headache and seizures to coma and death. For adults developing progressive neurological worsening despite adequate medical management, endovascular thrombolysis and/or mechanical thrombectomy may be considered as treatment options. We present one such patient with CVT who developed seizures and slipped into a coma, despite best medical management. A large-bore aspiration catheter was used as a standalone system for the endovascular procedure. The venous sinuses were successfully re-canalized. The patient was discharged a week later with a modified Rankin scale of 2. Studies show that endovascular thrombolysis used alone or in conjunction with thrombectomy for CVT has a higher risk of hemorrhagic complications. If we were to use mechanical thrombectomy devices (that are specifically designed for intracranial clot retrieval) as a stand-alone system, we would probably have better clinical outcomes with a lower risk of hemorrhagic complications.


Cerebral venous thrombosis (CVT) is a rare clinical entity and accounts for <1% of all strokes, with a wide array of clinical presentations from headache and seizures to coma and death [1-3]. For adults who develop progressive neurological worsening despite adequate medical management, endovascular thrombolysis and/or mechanical thrombectomy may be considered as treatment options [4]. When patients present with hemorrhagic venous infarcts, the treating physicians are often apprehensive to use endovascular thrombolytic agents, and there is limited evidence available about its effectiveness in such cases. We faced a similar dilemma, and we decided to use a large-bore aspiration catheter as a standalone system to successfully recanalize the cerebral venous system, which in turn resulted in a significant clinical improvement.


A patient in his late 30s presented to our institution with complaints of a recent headache. The headache had worsened and was severe at the time of presentation. He was coherent and had left-sided hemiparesis. We also noted bilateral papilledema. He underwent a computerized tomography scan which revealed hyperdensity along the right transverse and sigmoid sinuses. A provisional diagnosis of cerebral venous thrombosis was considered. The patient was admitted to the intensive care unit and was started on low molecular weight heparin. The following day, the patient developed focal seizures involving his left upper and lower limbs which progressed to epilepsia partialis continua. His sensorium started to deteriorate, and he was finally intubated, sedated, and paralyzed. Magnetic resonance imaging (MRI) of his brain revealed a bilateral venous infarct with hemorrhagic transformation and extensive thrombosis of superior sagittal sinus, inferior sagittal sinus, straight sinus, bilateral transverse sinus, right sigmoid sinus, and right internal jugular vein (Fig. 1 A, B). Since the patient was deteriorating despite best medical management, endovascular intervention was offered and informed consent was obtained.
Right femoral arterial access was obtained and a guiding catheter was placed in the left internal carotid artery with a constant heparinized saline flush. This system was used to acquire roadmaps, wherein the acquisition was continued until we could see the venous drainage. A 7 French short sheath was introduced into the left internal jugular vein under ultrasound guidance. Through this, a REACT 71 aspiration catheter (6.5 Fr, length 132 cm; Medtronic, Irvine, CA, USA) was introduced over a Phenom 21 microcatheter (0.021 inner diameter, 150 cm; Medtronic) and Avigo microwire (0.014 diameter, 205 cm; Medtronic) system (Fig. 1C). The catheter was slowly guided into the left and right transverse sinus, straight sinus, and inferior and superior sagittal sinuses. Aspiration thrombectomy was performed multiple times until recanalization was visible (Fig. 2A-D). The venous clots that were aspirated were red blood cell-rich clots (Fig. 1D). Both puncture sites were closed by manual compression. The patient was continued on low molecular weight heparin. The following day, the patient’s seizures had stopped. He was slowly weaned off the ventilator and extubated. Seven days from mechanical thrombectomy, the patient was discharged with residual hemiparesis on the left side and a modified Rankin Score of 2. Extensive investigations for prothrombotic states including anti-nuclear antibody profile, antiphospholipid antibody tests, and screening for protein C, protein S, or antithrombin III deficiencies were negative. His homocysteine levels were normal. He was discharged with oral anticoagulants.


CVT is an uncommon cause of stroke. According to the international study on cerebral vein and dural sinus thrombosis, despite best medical management 13.6% of patients still have bad outcomes with a mortality rate of 8.3% after an average follow-up of 16 months [5]. In such patients, endovascular therapy could be offered as a treatment option. The major indications for endovascular therapy in CVT include a) clinical deterioration or progression of intracerebral hemorrhage/venous infarction despite anticoagulation, b) severe stupor, comatose presentation, c) deep CVT, d) posterior fossa involvement, and e) major contraindication to anticoagulation such as bleeding disorders, thrombocytopenia (<100×109/L) or recent gastrointestinal hemorrhages [6]. Recently, a group of authors classified the configuration of CVT into 4 types: a) Type A: partial thrombosis of a sinus, b) Type B: complete thrombosis of the sinus without cortical vein involvement, c) Type C: cortical vein thrombosis only, and d) Type D: complete thrombosis of the sinus with cortical vein involvement [7]. Applying this classification, our patient had a Type D configuration CVT. According to this study, Type D patients have greater disease severity and poorer outcomes and mortality in the acute phase. Endovascular treatment as a salvage treatment was recommended for these patients [7]. When endovascular therapy is considered for CVT, 3 major treatment approaches have been followed: a) mechanical thrombectomy (using distal access catheter, thrombectomy devices, stent retrievers, or balloons), b) intravascular thrombolysis, or c) a combination of both. Studies indicate that endovascular treatment with thrombolytic agents has little benefit with an increased risk of hemorrhagic complications [8-10]. However when mechanical thrombectomy is used as the primary treatment modality for complicated CVT, the risk of hemorrhagic complications is lower, but with lower recanalization rates [11].
While it has been suggested that mechanical thrombectomy therapies may be superior to on-site thrombolytic therapy due to decreased risk of iatrogenic hemorrhage, the choice of mechanical thrombectomy method remains unclear. Stent retriever thrombectomy devices for treatment of CVT were first described by Froehler [12] in 2013. Although there are newer stent retrievers that are available for acute ischemic stroke, the use of these devices for CVT has not significantly affected outcomes or complete recanalization rates [13]. For diffuse CVT involving venous channels of different diameters, with varying lengths of occlusion, stent retrievers would not be an ideal device for thrombectomy [7]. In addition, deploying stent retrievers across each of the occluded sinuses, at various distances, and then retrieving them would significantly increase the intraoperative procedure time. Balloon angioplasty with or without stent deployment has also been tried in CVT, but then again there is very little literature in support of this method [14,15]. Balloon angioplasty would be helpful in disrupting clots, but would still require a distal aspiration system to assist thrombectomy.
Aspiration catheters have been successfully used for the treatment of CVT in the past. But there has been difficulty in tracking these devices up into the sinuses due to steep angles at various junctions [16]. In such instances, a stent retriever or a balloon can play the role of an anchor to assist in navigating these devices into the sinuses [16-18]. But the aspiration catheters used in these cases were older generation reperfusion catheters. Newer generation reperfusion catheters, with a larger inner diameter and better conformability have since then been used for acute ischemic stroke treatment (Table 1). However, their use in CVT has not yet been explored.
Taking the above factors into consideration, we decided to use a larger aspiration catheter system that was specifically designed for intracranial thrombectomy (REACT 71 aspiration catheter 6.5 Fr, length 132 cm; Medtronic). REACT 71 has a large inner diameter of 0.071 inches and is the only aspiration catheter that is reinforced with nitinol coils and braids both in proximal and distal shafts (implying better conformability and trackability). We decided not to use thrombolytic agents, in view of the hemorrhagic nature of the patient’s venous infarct. This intervention resulted in recanalization of the veins as mentioned above. With regards to the catheter insertion site, we decided to puncture the jugular vein directly and introduce a short sheath. Various studies have previously indicated that the risk of catheter-related thrombosis is higher in the femoral venous system when compared with the jugular venous system [19-21]. This also resulted in reducing the distance from the sheath to the target and thereby eliminated the need for a longer catheter/sheath system.
To the best of our knowledge, this is the first case report describing the REACT 71 aspiration catheter being used in the treatment of cerebral vein thrombosis. More controlled studies analyzing the benefits of intracranial aspiration catheter devices as a standalone therapy for complicated CVTs are needed.




Ethics Statement

Compliant with HIPAA guidelines.

Conflicts of Interest

The authors have no conflicts to disclose.

Author Contribution

Concept and design: KS. Analysis and interpretation: SP. Data collection: HH. Writing the article: JS. Critical revision of the article: SRC. Final approval of the article: SKP. Overall responsibility: KS.

Fig. 1.
(A) Magnetic resonance imaging brain T2 FLAIR images showing hemorrhagic venous infarct in the right cerebral hemispheres. (B) Magnetic resonance imaging venogram shows non visualization (white arrows) of major sinus conduits. (C) Aspiration catheter (black arrows) in the venous system. (D) Photomicrograph of blood clot showed predominantly red blood cells (black arrows) and very little fibrin (white arrow).
Fig. 2.
Pre (A, B) and post (C, D) venous mechanical thrombectomy.
Table 1.
Comparison of various intracranial aspiration thrombectomy catheters
Product name (company) Length (cm) Proximal OD (inch) Distal OD (inch) Distal ID (inch)
5 max Reperfusion Catheter (Penumbra) 132 0.080 0.065 0.054
ACE 64 (Penumbra) 132 0.080 0.075 0.064
ACE 68 (Penumbra) 132 0.080 0.080 0.068
Jet 7 (Penumbra) 132 0.085 0.075 0.072
ARC (Medtronic) 132 0.080 0.069 0.061
Catalyst 6 (Stryker) 132 0.079 0.071 0.060
Catalyst 7 (Stryker) 125/132 0.0825 0.082 0.068
Sofia (Microvention) 125 0.068 0.068 0.055
Sofia Plus (Microvention) 125/131 0.083 0.082 0.070
React 68 (Medtronic) 132 0.083 0.083 0.068
React 71 (Medtronic) 132 0.085 0.085 0.071

OD, outer diameter; ID, inner diameter.


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